The last proposed system of RBC vasodilation in the presence of nitrite is the reduction of nitrite to NO by Hb. Brooks very first examined the nitrite Hb interaction in 1937 and this operate was afterwards extended by Doyle in 1981 (Brooks, 1937; Doyle et al., 1981). Nitrite reacts with deoxygenated Hb to type metHb and NO (Brooks, 1937; Doyle et